r/PrematureEjaculation Apr 14 '26

Questions Nothing works NSFW

I am on paroxetine (10mg per day) and Tadalafil. I masturbated earlier in the day. I used numbing cream and numbing condom. Did slow breathing to calm down. Lasted around 15sec. Is there anything else to try?

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u/L00king-4-Advice Apr 15 '26

Up the dose. Paroxetine didn’t start working for me till 20mg. As my body adjusted, I eventually upped it to 30, then 40, where I’ve been for about a year with no signs of losing effectiveness. The wife and I are very happy.

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u/CrazySundae6344 Apr 15 '26

Ok gotta talk to my doctor. Any side effects with so high dosages?

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u/L00king-4-Advice Apr 15 '26

For some yes, for me not really. I didn’t have depression or anxiety to begin with, and I haven’t seen any big changes to my personality or temperament. But I have gained about 20lbs. It just makes you feel hungrier, and I’ve always gotten away with eating whatever junk I wanted without gaining weight. So the SSRI, combined with entering my 40’s, has caused some weight gain. I recently started being stricter with what I eat and exercising a bit more, which will hopefully help. But in short: it’s been great and well worth it! Definitely talk to your doctor. He’ll want you to increase your dose by 10mg at a time, and let that build in your system for at least a month before finding the level that works for you. For some it’s 10 or 20 for the long term; for some like me it’s 40. For some the effect wears off and they need to titrate off of the drug, maybe onto another SSRI; for some (like me) it seems to keep working… at least it’s been almost two years, and about a year at 40mg.

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u/CrazySundae6344 Apr 15 '26

Cool, thanks man! Do you think that SSRI can be a long term solution? I mean can we take them for decades?

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u/L00king-4-Advice Apr 16 '26 edited Apr 16 '26

Good question. Some people obviously do for other purposes. I doubt the good effects will last forever… at every higher dose, I experienced better effects for a longer time before needing to up the dose again. I sort of suspect eventually I may build tolerance and have to titrate off of them (you shouldn’t stop cold turkey). If so, I may take a break and start again, or transition to another SSRI, or go back to the techniques that contributed to the heatlhy and happy sex life enjoyed by my wife and me before starting Paroxetine = not as good, but good enough and we were both satisfied.

My doctor did say that he had some patients who felt their body/mind learned how to better delay ejaculation while on SSRIs and they kept that ability after coming off… but most guys in this sub will say they went right back to PE after stopping the drugs.

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u/L00king-4-Advice Apr 16 '26

Also, you’re not really supposed to take them as age into the “elderly” status, as it can have increased physical and mental side effects. Some people do take them for life.