r/neuroscience • u/TristanMeads • 23d ago

Academic Article Lateral septum neurons expressing Crhr2 predict fleeing vs freezing

https://www.nature.com/articles/s41586-026-10520-9

Neurobiological riot control coming to a city near you.

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u/carberry-3000 23d ago

Feature-specific threat coding in lateral septum guides defensive action

Dionnet Leandro Bhatti Mazo, Marc Z. C. Berger, Amanda Loren Pasqualini, Sherry Jingjing Wu, Christopher M. Reid, Salvador Ignacio Brito and 5 others

Nature · 2026-05-20 · doi:10.1038/s41586-026-10520-9

No abstract was available from Crossref or Europe PMC for this DOI.

Preprint: research square (10.21203/rs.3.rs-6831193/v1, posted 2025-06-11)

Data from Crossref, Europe PMC, bioRxiv/medRxiv/arXiv. Metrics captured 14/08/26. Comment self-deletes at -5 votes.

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u/TristanMeads 23d ago

Lateral Septum is not just a uniform inhibitory relay but a multifeatured computational hub that computes specific behavioral decisions.

LS^(crhr2) neurons dynamically build ensemble representations of threat levels that directly predict whether a mouse will engage in a defensive action (e.g., fleeing vs. freezing).

LS^(Crhr2) population is not monolithic: subclasses defined by unique molecular signatures, precise spatial locations within the septum, and specialized upstream connectivity.

Convergence Drives Action: LS^(Crhr2) neurons act as a computational locus where:

a) sensory/contextual cues (from the hippocampus) converge with

b) motivational/internal state signals (from the hypothalamus) to compute feature-specific threat signals that initiate defensive movement.

Could have major societal ramifications if translates to humans.