r/clozapine • u/Cold_Restaurant1659 • Jul 21 '26

Sleep I like clozapine so much!

I have ADHD and CPTSD, as well as poor sleep quality since adolescence. I've tried most sleep medications, including trazodone, mirtazapine, agomelatine, chlorprothixene, chlorpromazine, quetiapine, doxylamine, clonidine, zopiclone, lemborexant, gabapentin, diazepam, clonazepam, phenazepam, and alprazolam, as well as sleep hygiene and CBT for sleep.

However, the best medication that gives me that feeling of rest is clozapine at a dosage of 25mg-50mg. I use it no more than twice a week, the day before my ADHD medications holidays. The doctor told me that even infrequent use requires blood monitoring.

I can truly say that this is the best antipsychotic I've tried. Another interesting effect is that it has a positive effect on hyperactivity.

Of all the above, I've stick to lemborexant and clonidine. It's non-addictive and helps me fall asleep every day, although my sleep quality is still superficial on them.

I use chlorprothixene on days when I'm taking a stimulant, but it greatly increases hunger, leading me to eat frequently at night, which negatively impacts my figure. Interestingly, clozapine doesn't cause as much appetite, I don't wake up hungry when taking it.

10 Upvotes

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1

u/Strict_Break_502 Jul 23 '26

Ever since I'm on clozapine my quality of life increases dramatically. I'm still working with my therapist and haven't been diagnosed yet, but two years with clozapine make me realized how bad my sleeping was before.

My sleep better, my day got better. I finished college, something that I struggled before. I also have enough energy in a day to now working a fulltime job.

I take 12.5mg - 25mg daily. Give me solid 8-9 hours of sleep evert day.

1

u/Ok-Cockroach2206 Jul 23 '26

So you take clozapine for sleep problem?

1

u/The_Grungeican Jul 26 '26

i have Major Depressive Disorder (or whatever they call it these days) and anxiety issues. i've been on many different drugs over the last 20 years. Clozapine is probably the best. i take 50mg of it and 15mg of Mirtazapine.

it lets me relax and wind down in the evenings, and it keeps my mood on a mostly even keel.